Received: Accepted: JPublished: July 21, 2023Ĭopyright: © 2023 Al-Khatib et al. A larger cohort study is needed to further investigate our results.Ĭitation: Al-Khatib SM, Ababneh O, Abushukair H, Abdo N, Al-Eitan LN (2023) The impact of IDH and NAT2 gene polymorphisms in acute myeloid leukemia risk and overall survival in an Arab population: A case-control study. These results were also similar in the TCGA-LAML cohorts with the notable exception of the rare NAT2 mutation. Our study indicates that NAT2 rs1799930 SNP had a statistically significant difference in genotype frequency between cases and controls (p = 0.023) while IDH mutations did not correlate with the risk and survival of AML in the Jordanian population. Genotyping of the genetic polymorphisms was conducted using a sequencing protocol. For AML patients (case group) Genomic DNA was extracted from formalin-fixed paraffin-embedded tissues and from peripheral blood samples for the control subjects group. Females comprised 50% (n = 15) and 65.3% (n = 147) of patients and controls, respectively. A total number of 30 AML patients and 225 healthy controls were included in this study. In this study, we analyzed the relationship between five, not previously studied in any Arab population, single nucleotide polymorphisms (SNPs) and the risk and overall survival of AML in Jordanian patients. Such genetic aberrations include FLT3, DNMT3, IDH1, IDH2, NAT2, and WT. The etiology of AML is complex and involves environmental and genetic factors. Acute myeloid leukemia (AML) is a malignancy of the myeloid cells due to the clonal and malignant proliferation of blast cells.
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